Bremelanotide Injections are designed for premenopausal women experiencing Hypoactive Sexual Desire Disorder (HSDD), a condition where there is a distressing lack of sexual desire that is not related to other medical or psychological factors. Unlike hormone-based treatments, Bremelanotide works on the central nervous system, making it an innovative, fast-acting solution that addresses sexual motivation and arousal directly.
Mechanism of Action:
Bremelanotide is a melanocortin receptor agonist, which means it stimulates melanocortin receptors in the brain, particularly those involved in sexual arousal and desire. By working on neurotransmitters like dopamine, which plays a key role in reward and sexual motivation, bremelanotide helps increase sexual desire in women.
Unlike medications that target blood flow, such as sildenafil, bremelanotide works by activating pathways in the brain associated with sexual desire, offering a non-hormonal approach that directly enhances sexual arousal.
How to Use:
- Administer the injection subcutaneously about 45 minutes before anticipated sexual activity.
- Dosing: The recommended dose is 1.75 mg injected under the skin. The injection should not be used more than once in 24 hours and should not exceed 8 doses per month.
- It is important to follow medical guidance closely and not exceed the prescribed dosage to avoid potential side effects.
Potential Benefits:
- Increased Sexual Desire: Specifically designed for women diagnosed with HSDD, bremelanotide enhances sexual desire by targeting brain pathways responsible for arousal.
- Non-Hormonal Option: This treatment does not involve hormones, making it a suitable option for women who prefer to avoid hormone-related therapies like testosterone.
- Fast-Acting: Bremelanotide works quickly, making it convenient for use shortly before sexual activity, providing an immediate boost in sexual motivation.
Evidence Supporting Bremelanotide:
Studies have shown that bremelanotide significantly improves sexual desire in premenopausal women with HSDD compared to placebo. Unlike daily-use alternatives bremelanotide offers an on-demand solution with immediate effects. Women who use bremelanotide report an improvement in sexual desire and reduced distress related to HSDD.
Common Side Effects:
- Nausea (most common side effect)
- Flushing or warmth in the face
- Headache
- Increased Blood Pressure: Bremelanotide can cause temporary increases in blood pressure, so it should be used with caution in individuals with cardiovascular conditions.
- Skin Darkening: Prolonged use has been associated with hyperpigmentation in certain areas of the skin.
Contraindications:
- Uncontrolled Hypertension: Bremelanotide can cause a temporary rise in blood pressure, so it should not be used by individuals with uncontrolled high blood pressure.
- Cardiovascular Disease: Those with a history of cardiovascular disease should consult their healthcare provider before using this treatment due to potential blood pressure changes.
Comparisons with Other Treatments:
Compared to other FDA-approved treatments for HSDD, bremelanotide stands out due to its on-demand nature. Bremelanotide is administered as needed and has an immediate effect on sexual desire.
Key Points:
- Bremelanotide Injections are a fast-acting, non-hormonal option specifically designed to treat HSDD in premenopausal women.
- It is not intended for use in treating sexual dysfunction caused by other factors, such as relationship problems, medical conditions, or stress.
- Women with pre-existing health conditions, particularly those related to blood pressure or cardiovascular issues, should use bremelanotide under medical supervision due to its potential to cause increases in blood pressure.
This treatment offers an effective, safe, and convenient way to enhance sexual desire, allowing women to regain confidence and experience a renewed sense of intimacy.
